Design, synthesis, cytotoxic evaluation, and QSAR study of some 6H-indolo[2,3-b]quinoxaline derivatives

✍ Scribed by Hari Narayana Moorthy, N. S.; Karthikeyan, C.; Trivedi, Piyush

• Book ID: 121273992
• Publisher: Informa plc
• Year: 2010
• Tongue: English
• Weight: 865 KB
• Volume: 25
• Category: Article
• ISSN: 1475-6366
• DOI: 10.3109/14756360903190747

✦ Synopsis

In the pathway of anticancer drug development, we designed and synthesized some 6H-indolo[2,3-b]quinoxaline derivatives (which act as DNA intercalators) by structural modification. The structure of the 6H-indolo[2,3-b]quinoxaline derivatives was confirmed by IR, NMR, Mass and elemental analysis. The compounds (IDQ-5, IDQ-10, IDQ-11, IDQ-13, and IDQ-14) exhibited significant in vitro activity against a human leukemia (HL-60) cell line. The QSAR derived for modeling the cytotoxic activity of 6H-indolo[2,3-b]quinoxaline derivatives suggests that candidate structures for increased cytotoxic potency should incorporate cyclic substituents or substituents with primary carbon atoms.