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Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors

✍ Scribed by Aleem Gangjee; Wei Li; Lu Lin; Yibin Zeng; Michael Ihnat; Linda A. Warnke; Dixy W. Green; Vivian Cody; Jim Pace; Sherry F. Queener


Book ID
108072710
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
994 KB
Volume
17
Category
Article
ISSN
0968-0896

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## Abstract Receptor tyrosine kinases such as VEGFR2 (vascular endothelial growth factor receptor 2, KDR) or EGFR (epidermal growth factor receptor) play crucial roles in a variety of diseases, such as cancer. Recently, some pyrrolopyrimidines were shown to be potent EGFR inhibitors. Therefore, new