## Abstract Nonclassical 2,4βdiaminoβ5βsubstituted furo[2,3β__d__]pyrimidines **4aβi, 5aβb** and **7aβf** were synthesized as extended aromatic ring appended analogs of previously reported antifolates **1aβb.** The extended aromatic system was designed to better interact with a phenylalanine residu
Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors
β Scribed by Aleem Gangjee; Wei Li; Lu Lin; Yibin Zeng; Michael Ihnat; Linda A. Warnke; Dixy W. Green; Vivian Cody; Jim Pace; Sherry F. Queener
- Book ID
- 108072710
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 994 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0968-0896
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Nine novel nonclassical 2,4-diamino-6-methyl-5-thioarylsubstituted-7H-pyrrolo [2,3-d]pyrimidines 2-10 were synthesized as potential inhibitors of dihydrofolate reductase and as antitumor agents. The analogues contain various electron donating and electron withdrawing substituents on the phenylsulfan
## Abstract Receptor tyrosine kinases such as VEGFR2 (vascular endothelial growth factor receptor 2, KDR) or EGFR (epidermal growth factor receptor) play crucial roles in a variety of diseases, such as cancer. Recently, some pyrrolopyrimidines were shown to be potent EGFR inhibitors. Therefore, new