Design, synthesis, and structure–activity relationships of indole-3-carboxamides as novel water soluble cannabinoid CB1 receptor agonists
✍ Scribed by Adam, Julia M.; Cairns, Jim; Caulfield, Wilson; Cowley, Phillip; Cumming, Iain; Easson, Morag; Edwards, Darren; Ferguson, Morag; Goodwin, Richard; Jeremiah, Fiona
- Book ID
- 115472087
- Publisher
- The Royal Society of Chemistry
- Year
- 2010
- Tongue
- English
- Weight
- 158 KB
- Volume
- 1
- Category
- Article
- ISSN
- 2040-2503
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📜 SIMILAR VOLUMES
Novel indole-3-heterocycles were designed and synthesized and found to be potent CB1 receptor agonists. Starting from a microsomally unstable lead 1, a bioisostere approach replacing a piperazine amide was undertaken. This was found to be a good strategy for improving stability both in vitro and in
## Abstract The discovery, synthesis, and SAR of a novel series of cannabinoid 1 (CB~1~) and cannabinoid 2 (CB~2~) receptor ligands are reported.