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Design, synthesis and structure of new chiral squaric acid monoaminoalcohols and diaminoalcohols and their use as catalysts in asymmetric reduction of ketones and diketones
✍ Scribed by Hai-Bing Zhou; Ji Zhang; Shou-Mao Lü; Ru-Gang Xie; Zhong-Yuan Zhou; Michael C.K Choi; Albert S.C Chan; Teng-Kuei Yang
- Book ID
- 108371389
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 240 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0040-4020
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📜 SIMILAR VOLUMES
Two series of new chiral ligands, squaric acid aminoalcohols and C 2 -symmetric squaric acid diaminoalcohols have been synthesized. The chiral oxazaborolidines formed in situ from these ligands have been used in the enantioselective borane reduction of prochiral ketones and diketones to afford alcoh
## Abstract A new __C__~2~‐symmetric chiral catalyst 3,5‐bis[(2__S__)‐(hydroxy‐diphenylmethyl)‐ pyrrolidin‐1‐ylmethyl]‐1,3,4‐oxadiazole was successfully synthesized by the reaction of 2,5‐dichloromethyl‐1,3,4‐oxadiazole with (__S__)‐α,α‐diphenyl‐2‐pyrrolidinemethanol, and applied to the catalytic a