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Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1,3-propanediols: Discovery of a novel immunosuppressant, FTY720

✍ Scribed by Kunitomo Adachi; Toshiyuki Kohara; Noriyoshi Nakao; Masafumi Arita; Kenji Chiba; Tadashi Mishina; Shigeo Sasaki; Tetsuro Fujita

Book ID
103982902
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
190 KB
Volume
5
Category
Article
ISSN
0960-894X

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✦ Synopsis

ethyl]-l,3-propanediol hydrochloride), a novel synthetic immunosuppressant led by modification of ISP-I (myriocin, thermozymocidin) displayed potent immunosuppressive activity both b~ ~tro and/~ vivo.

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