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Design, synthesis and potent cytotoxic activity of novel podophyllotoxin derivatives

โœ Scribed by Li, Wen-Qun; Wang, Xu-Li; Qian, Keduo; Liu, Ying-Qian; Wang, Chih-Ya; Yang, Liu; Tian, Jin; Morris-Natschke, Susan L.; Zhou, Xing-Wen; Lee, Kuo-Hsiung

Book ID
120488277
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
395 KB
Volume
21
Category
Article
ISSN
0968-0896

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One-pot syntheses of 4'-demethylepipodophyllotoxin 7 and NPF 2 (4'-0demethyl-4[~-(4"-fluoroanilino)-4-deoxypodophyllotoxin) are described from podophyllotoxin 3 via a protocol using trimethylsilyl iodide in 72% and 52% overall yields, respectively.