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Design, synthesis and pharmacological activities of 2-substituted 4-phenylquinolines as potential antidepressant drugs

✍ Scribed by Alhaider, Abdulqader A.; Abdelkader, M. Atef; Lien, Eric J.


Book ID
120181141
Publisher
American Chemical Society
Year
1985
Tongue
English
Weight
652 KB
Volume
28
Category
Article
ISSN
0022-2623

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## Abstract Substituted 4‐heteroaryl‐2‐phenylquinolines were synthesized and tested on NK‐2 and NK‐3 receptors in order to get a better insight in the structure‐activity relationship. On the whole, these molecules, which can be regarded as bioisosters of the NK‐3 antagonist SB 218795, displayed a l