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Design, synthesis and molecular docking of some new 1,2,4-triazolobenzimidazol-3-yl acetohydrazide derivatives with anti-inflammatory-analgesic activities

✍ Scribed by Mohammed, Anber F.; Abdel-Moty, Samia G.; Hussein, Mostafa A.; Abdel-Alim, Abdel-Alim M.


Book ID
120508607
Publisher
Springer
Year
2013
Tongue
English
Weight
686 KB
Volume
36
Category
Article
ISSN
0253-6269

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A series of 3-(4,6-disubtituted-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl) propanoic acid derivatives has been synthesized by condensation of thiourea, 5-(4-subtituted phenyl)-5-oxopentanoic acid and substituted aldehyde. The synthesized compounds were screened for their anti-inflammatory activity u