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Design, Synthesis, and in Vitro Evaluation of Dipeptide-Based Antibody Minor Groove Binder Conjugates

✍ Scribed by Jeffrey, Scott C.; Torgov, Michael Y.; Andreyka, Jamie B.; Boddington, Laura; Cerveny, Charles G.; Denny, William A.; Gordon, Kristine A.; Gustin, Darin; Haugen, Jennifer; Kline, Toni; Nguyen, Minh T.; Senter, Peter D.


Book ID
120344927
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
308 KB
Volume
48
Category
Article
ISSN
0022-2623

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The design, synthesis and in vitro biological evaluation of pyridinium ion based inhibitors of oxidosqualene cyclase enzymes are reported. N-Alkyland N-prenylpyridinium ions have been found to be potent and specific inhibitors of Candida albicans oxidosqualene-lanosterol cyclase and to exhibit antif