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Design, synthesis, and evaluation of substituted 6-amide-4-anilinoquinazoline derivatives as c-Src inhibitors

✍ Scribed by Fang, Fei; Li, Dong-Dong; Li, Jing-Ran; Sun, Jian; Du, Qian-Ru; Gong, Hai-Bin; Zhu, Hai-Liang


Book ID
124096326
Publisher
The Royal Society of Chemistry
Year
2013
Tongue
English
Weight
740 KB
Volume
3
Category
Article
ISSN
2046-2069

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Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a crucial role in the process of cancer angiogenesis. A series of quinoline amide derivatives were prepared and found to be good inhibitors of VEGFR-2. The inhibitory activities were investigated against VEGFR-2 kinase and human umbilical