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Design, synthesis, and evaluation of cyclofenil derivatives for potential SPECT imaging agents

✍ Scribed by Hua Zhu; Liliang Huang; Yuanqing Zhang; Xiaoping Xu; Yanhong Sun; Yu-Mei Shen

Book ID
106232449
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
376 KB
Volume
15
Category
Article
ISSN
1432-1327

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## Abstract Iodocaramiphen (2) is a selective muscarinic antagonist which binds __in vitro__ with high affinity and selectivity to the M~1~ subtype of the muscarinic receptor. We report the synthesis of iodine‐125 labeled iodocaramiphen ([^125^I]‐2) via a tributylstannyl intermediate (3) in 50% rad