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Design, synthesis and docking study of 5-(substituted benzylidene)thiazolidine-2,4-dione derivatives as inhibitors of protein tyrosine phosphatase 1B

โœ Scribed by Wang, Zengtao; Liu, Zhiguo; Lee, Woojung; Kim, Su-Nam; Yoon, Goo; Cheon, Seung Hoon


Book ID
124139795
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
789 KB
Volume
24
Category
Article
ISSN
0960-894X

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A series of substituted phenoxy-3-piperazin-1-yl-propan-2-ols has been synthesized and evaluated for PTP1B inhibitory activity in vitro and for antidiabetic activity in vivo. Two molecules viz. 4a and 5b showed PTP1B inhibition of 31.58% and 35.90% at 100 ฮผM concentration. The compound 4a also showe