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Design, Synthesis, and Biological Properties of New Bis(acridine-4-carboxamides) as Anticancer Agents

✍ Scribed by Antonini, Ippolito; Polucci, Paolo; Magnano, Amelia; Gatto, Barbara; Palumbo, Manlio; Menta, Ernesto; Pescalli, Nicoletta; Martelli, Sante


Book ID
120297896
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
116 KB
Volume
46
Category
Article
ISSN
0022-2623

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A new synthesis of substituted acridine-
✍ Swarna A. Gamage; Julie A. Spicer; Gordon W. Rewcastle; William A. Denny πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 French βš– 201 KB

A new synthesis of substituted acridine-4-carboxylic acids 2 from methyl 2-[N-(2-earboxyphenyl)amino]benzoates (4) is reported, via NaBH4 reduction of the corresponding imidazolides (5), oxidation of the resulting alcohols 6 to aldehydes 7, and cyclisation of these with trifluoroacetic acid to the m