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Design, synthesis and biological evaluation of novel aminothiazoles as antiviral compounds acting against human rhinovirus

✍ Scribed by Décor, Anne; Grand-Maître, Chantal; Hucke, Oliver; O’Meara, Jeff; Kuhn, Cyrille; -Forget, Léa Constantineau; Brochu, Christian; Malenfant, Eric; Bertrand-Laperle, Mégan; Bordeleau, Josée; Ghiro, Elise; Pesant, Marc; Fazal, Gulrez; Gorys, Vida; Little, Michael; Boucher, Colette; Bordeleau, Sylvain; Turcotte, Pascal; Guo, Tim; Garneau, Michel; Spickler, Catherine; Gauthier, Annick


Book ID
120536334
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
682 KB
Volume
23
Category
Article
ISSN
0960-894X

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A series of chloro-pyridazine piperazines were developed based on the structure of human rhinovirus (HRV) capsid-binding inhibitors with proven activity using a pharmacophore model. A preliminary evaluation demonstrated potent activity against HRV-3 with low cytotoxicity. A docking analysis indicate