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Design, Synthesis, and Biological Evaluation of Hybrid Molecules Containing α-Methylene-γ-Butyrolactones and α-Bromoacryloyl Moieties

✍ Scribed by Romagnoli, Romeo; Baraldi, Pier Giovanni; Tabrizi, Mojgan Aghazadeh; Bermejo, Jaime; Estévez, Francisco; Borgatti, Monica; Gambari, Roberto


Book ID
120228125
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
199 KB
Volume
48
Category
Article
ISSN
0022-2623

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## Abstract In a search for inhibitors of platelet aggregation, a number of α‐methylidene‐γ‐butyrolactones 5 and 6 bearing flavone or xanthone moieties, respectively, were synthesized and evaluated for their antiplatelet activity against thrombin(Thr)‐, arachidonic‐acid(AA)‐, collagen(Col)−, and pl