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Design, Synthesis, and Biological Evaluation of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-6-methylpyrrolo[3,2- d ]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors

โœ Scribed by Gangjee, Aleem; Li, Wei; Yang, Jie; Kisliuk, Roy L.


Book ID
120229554
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
250 KB
Volume
51
Category
Article
ISSN
0022-2623

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๐Ÿ“œ SIMILAR VOLUMES


Synthesis of classical and nonclassical
โœ Aleem Gangjee; Yibin Qiu; Roy L. Kisliuk ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› Journal of Heterocyclic Chemistry ๐ŸŒ English โš– 97 KB

## Abstract A series of seven nonclassical 2โ€aminoโ€4โ€oxoโ€6โ€substituted thieno[2,3โ€__d__]pyrimidines **2โ€8** and one classical __N__โ€[4โ€(2โ€aminoโ€4โ€oxoโ€3,4โ€dihydrothieno[2,3โ€__d__]pyrimidinโ€6โ€ylmethyl)benzoyl]โ€Lโ€glutamic acid **9** (Table I) were designed as the first in a series of 6โ€substituted 6โ€5