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Design, Synthesis and Biological Evaluation of Caffeic Acid Amides as Selective MMP-2 and MMP-9 Inhibitors

✍ Scribed by Zhi-Hao Shi; Nian-Guang Li; Qian-Ping Shi; Hao Tang; Yu-Ping Tang; Wei Li; Lian Yin; Jian-Ping Yang; Jin-Ao Duan


Book ID
115555078
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
220 KB
Volume
73
Category
Article
ISSN
0272-4391

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Design, synthesis and biological evaluat
✍ Ying Yang; Lei Shi; Yang Zhou; Huan-Qiu Li; Zhen-Wei Zhu; Hai-Liang Zhu πŸ“‚ Article πŸ“… 2010 πŸ› Elsevier Science 🌐 English βš– 321 KB

Vascular endothelial growth factor receptor-2 (VEGFR-2) plays a crucial role in the process of cancer angiogenesis. A series of quinoline amide derivatives were prepared and found to be good inhibitors of VEGFR-2. The inhibitory activities were investigated against VEGFR-2 kinase and human umbilical