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Design, synthesis, and biological evaluation of a dansyled amino acid derivative as an imaging agent for apoptosis

✍ Scribed by Wenbin Zeng; Weimin Miao; George Kabalka; Michael Le Puil; John Biggerstaff; David Townsend

Publisher: Elsevier Science
Year: 2008
Tongue: French
Weight: 600 KB
Volume: 49
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2008.08.091

No coin nor oath required. For personal study only.

✦ Synopsis

To develop a small molecule-based biomarker for in vivo apoptosis imaging, a dansyled amino acid derivative (BNSBA) was designed and synthesized in good yield. The biological evaluation demonstrated that BNSBA selectively binds to apoptotic cancer cells and is localized within the cytoplasm of cells that bound annexin V on the plasma membrane.

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