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Design, Synthesis, and Biological Activities of New Thieno[3,2-d]pyrimidines as Selective Type 4 Phosphodiesterase Inhibitors1

✍ Scribed by Crespo, María I.; Pagès, Lluís; Vega, Armando; Segarra, Victor; López, Manel; Doménech, Teresa; Miralpeix, Montserrat; Beleta, Jordi; Ryder, Hamish; Palacios, José M.

Book ID: 111645498
Publisher: American Chemical Society
Year: 1998
Tongue: English
Weight: 300 KB
Volume: 41
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm981012m

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## Abstract Three previously undescribed dihydrofolate reductase (DHFR) inhibitors, N^α^‐[4‐[__N__‐[(2,4‐diaminopyrrolo[2,3‐__d__]pyrimidin‐5‐yl)methyl]amino]benzoyl]‐__N__^δ^‐hemiphthaloyl‐L‐ornithine **(7)**, __N__^α^‐ [4‐ [__N__‐[(2,4‐diaminothieno[2,3‐__d__]pyrimidin‐5‐yl)methyl]amino]benzoyl]‐