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Design, Synthesis and Antitumor Activity of Asymmetric Bis(s-triazole Schiff-base)s Bearing Functionalized Side-Chain

✍ Scribed by Guo-Qiang HU; Li-Li HOU; Song-Qiang XIE; Wen-Long HUANG

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
70 KB
Volume
26
Category
Article
ISSN
0256-7660

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✦ Synopsis

Abstract

1‐Amino‐2‐pyrid‐3‐yl‐5‐(2‐benzoylethylthio)‐s‐triazole (1) was condensed with 1‐amino‐3‐mercapto‐5‐ [(un)substituted phenyl]‐s‐triazoles and subsequently substituted with chloroacetic acid to afford bis‐s‐triazole sulfanylacetic acid mono‐Schiff bases (3a–3e), which were condensed with 9‐formylanthracene to produce asymmetric bis(s‐triazole Schiff base) sulfanylacetic acids (4a–4e). The structures of new synthesized compounds were characterized by elemental analysis and spectral data, and their in vitro antitumor activity against L1210, CHO and HL60 cell lines was evaluted via the respective IC~50~ values by methylthiazole trazolium (MTT) assay.

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ChemInform Abstract: Design, Synthesis a
ChemInform Abstract: Design, Synthesis and Antitumor Activity of Asymmetric Bis(s-triazole Schiff-Base)s Bearing Functionalized Side-Chain.
✍ Guo-Qiang Hu; Li-Li Hou; Song-Qiang Xie; Wen-Long Huang 📂 Article 📅 2008 🏛 John Wiley and Sons ⚖ 19 KB

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