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Design, Synthesis and Anti-HIV Activity of Homologous PMEA Derivatives

✍ Scribed by Oh, Chang Hyun; Hong, Joon Hee


Book ID
120507156
Publisher
Taylor and Francis Group
Year
2008
Tongue
English
Weight
128 KB
Volume
27
Category
Article
ISSN
0732-8311

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Synthesis of isomeric nucleoside phospho
✍ Xiaoping Zheng; Vasu Nair πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 French βš– 809 KB

Synthesis of cyclic analogs of the anti-HIV active acyclic nucleoside phosphonate, PMEA, is described. A key reaction in the synthesis was the stereoselective cyclization of an acyclic phosphonyl intermediate to a phosphonyltetrahydrofuran. Complete stereostructures of the target isomeric phosphony