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Design strategies for the construction of independently folded polypeptide motifs

โœ Scribed by Barbara Imperiali; Jennifer J. Ottesen

Publisher
Wiley (John Wiley & Sons)
Year
1998
Tongue
English
Weight
177 KB
Volume
47
Category
Article
ISSN
0006-3525

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โœฆ Synopsis

In this paper we present a redesign strategy for the development of uniquely folded polypeptide motifs of less than 40 residues. These mini proteins are based on natural target domains, including the zinc finger domains (BBA motif)* and the disulfide-rich snake and scorpion toxins (BBB motif). These motifs are designed to act as the molecular framework for the construction of novel functional polypeptides. We will explore the structural determinants of the folded BBA motif, inspired by the zinc finger peptides, in relation to the redesign process.

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