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DESIGN OPTIMIZATION OF A NEW POSTERIOR DYNAMIC STABILIZATION SYSTEM

✍ Scribed by Hans-Joachim Wilke; Frank Heuer; Hendrik Schmidt

Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
553 KB
Volume
41
Category
Article
ISSN
0021-9290

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## Abstract __A discovery strategy relying on the identification of fragments through resolution of a constitutional dynamic system, coupled to subsequent static ligand design and optimization, is demonstrated. The strategic design and synthesis of the best molecular fragments identified from a dyn