Design of Sequence-specific DNA Cleaving Molecules : Comparison of Distamycin-EDTA·Fe(II) and N-Bromoacetyldistamycin

Man-designed bleomycins. synthesis of di

Man-designed bleomycins. synthesis of dioxygen activating molecules and a DNA cleaving molecule based on bleomycin-Fe(II)-02 complex

✍ Atsushi Kittaka; Yuichi Sugano; Masami Otsuka; Masaji Ohno 📂 Article 📅 1988 🏛 Elsevier Science 🌐 French ⚖ 916 KB

A synthetic model for the metal binding site of bleomycin with a 4-methoxypyridine nucleus and a tert-butyl group is shown to be comparable to bleomycin interms of dioxygen activation. This model ligand is coupled with a DNA affinity moiety, tetrapeptide S, to afford a mandesigned bleomycin which e