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Design of Secondary Structures in Unnatural Peptides: Stable Helical γ-Tetra-, Hexa-, and Octapeptides and Consequences of α-Substitution

✍ Scribed by Hanessian, Stephen; Luo, Xuehong; Schaum, Robert; Michnick, Stephen


Book ID
125996759
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
55 KB
Volume
120
Category
Article
ISSN
0002-7863

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✍ Stephen Hanessian; Hua Yang 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 236 KB

The incorporation of a-substituted t-amino acids into a tetrapeptide motif induces a reverse turn in aprotic solvent systems as revealed by NOESY and ROESY techniques, and by CD spectra. The conformations of these compounds have been studied by mol ecul ar modeling, and further supported by performi