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Design of novel RNA ligands that bind stem–bulge HIV-1 TAR RNA

✍ Scribed by Duca, Maria; Malnuit, Vincent; Barbault, Florent; Benhida, Rachid


Book ID
120401919
Publisher
Royal Society of Chemistry
Year
2010
Tongue
English
Weight
636 KB
Volume
46
Category
Article
ISSN
1359-7345

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## Abstract Replication of human immunodeficiency virus type 1 (HIV‐1) requires specific interactions of the Tat protein with the transactivation responsive region (TAR) RNA. Tat‐TAR RNA Interaction is mediated by a short arginine‐rich domain of the protein. Disruption of this interaction could, in