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Design of Novel, Nonpeptidic Thrombin Inhibitors and Structure of a Thrombin–Inhibitor Complex

✍ Scribed by Dipl.-Chem. Ulrike Obst; Dr. Volker Gramlich; Prof. François Diederich; Dr. Lutz Weber; Dr. David W. Banner

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
478 KB
Volume
34
Category
Article
ISSN
0044-8249

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Structure-activity relationships for new members of a class of nonpeptidic, low-molecular-weight inhibitors of thrombin, a key serine protease in the blood coagulation cascade, are described. These compounds, which originate from X-ray-structure-based design, feature a conformationally rigid, bi-or