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Design of dimerization inhibitors of HIV-1 aspartic proteinase: A computer-based combinatorial approach

✍ Scribed by Amedeo Caflisch; Hans J. Schramm; Martin Karplus

Book ID
110259224
Publisher
Springer Netherlands
Year
2000
Tongue
English
Weight
398 KB
Volume
14
Category
Article
ISSN
0920-654X

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## Abstract A small peptide library of monocyclic SFTI‐1 trypsin inhibitor from sunflower seeds modified in positions P~1~ and P~4~β€² was synthesized using a portioning‐mixing method. The peptide library was deconvoluted by the iterative approach in solution. Two trypsin ([Met^9^]‐SFTI‐1 and [Arg^5^