✦ LIBER ✦

Design of biopharmaceutical properties through prodrugs and analogs. Edited by Edward B. Roche. American Pharmaceutical Association, 2215 Constitution Avenue, N.W., Washington, DC 20037. 1977.455 pp. 16 × 23 cm. Price $20.00, $13.00 Member Rate

✍ Scribed by Henry C. Caldwell

Publisher: John Wiley and Sons
Year: 1978
Tongue: English
Weight: 137 KB
Volume: 67
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600670254

No coin nor oath required. For personal study only.

✦ Synopsis

free of these interferences and only measures the "true" creatinine.

The boiling alkaline picrate method has been claimed to measure the true creatinine (5). The results of the present study do not support the claim. In a previous study (3), the "apparent" recovery of the spiked creatinine in plasma was only 81% and, after heat treatment, certain components in plasma were thought to suppress the creatinine-picrate complex reaction or to interfere with the color formation. Thus, the reason for the higher creatinine values by the boiling alkaline picrate method remains to be determined.

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