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Design of Acid−Base Catalysis for the Asymmetric Direct Aldol Reaction

✍ Scribed by Saito, Susumu; Yamamoto, Hisashi


Book ID
120173681
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
506 KB
Volume
37
Category
Article
ISSN
0001-4842

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Tandem and two-directional asymmetric ca
✍ Koichi Mikami; Satoru Matsukawa; Masako Nagashima; Hiroshi Funabashi; Hajime Mor 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 257 KB

Upon addition of an excess amount of an aldehyde 3, the Mukaiyama aldol reaction of a silyl enol ether 2 proceeds in tandem and two-directional fashion by the asymmetric catalysis of a binaphthol-derived chiral titanium complex (BINOL-Ti: 1) to give the silyl enol ether 4 in 77% isolated yield in mo