Design of a series of bicyclic HIV-1 int
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Eric D. Jones; Nick Vandegraaff; Giang Le; Neil Choi; William Issa; Katherine Ma
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Article
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2010
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Elsevier Science
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English
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HIV integrase inhibitors based on a novel bicyclic pyrimidinone core is presented. Nine variations of the core scaffold are evaluated leading to optimization of the 6:6 core giving compound 48 with an EC 50 of 3 nM against wild type HIV infected T-cells.