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Design of a Protein Potential Energy Landscape by Parameter Optimization

✍ Scribed by Lee, Julian; Kim, Seung-Yeon; Lee, Jooyoung


Book ID
126177331
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
639 KB
Volume
108
Category
Article
ISSN
0022-3654

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A novel hierarchical approach to protein folding has been applied to compute the unknown structures of seven target proteins provided by CASP3. The approach is based exclusively on the global optimization of a potential energy function for a united-residue model by conformational space annealing, fo