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Design of a helical motif using .alpha.,.beta.-dehydrophenylalanine residues: crystal structure of Boc-Val-.DELTA.Phe-Phe-Ala-Phe-.DELTA.Phe-Val-.DELTA.PHe-Gly-OCH3, a 310-helical nonapeptide

✍ Scribed by Rajashankar, K. R.; Ramakumar, S.; Chauhan, V. S.


Book ID
121333738
Publisher
American Chemical Society
Year
1992
Tongue
English
Weight
293 KB
Volume
114
Category
Article
ISSN
0002-7863

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Design of peptides: Crystal and molecula
✍ B. Padmanabhan; T. P. Singh πŸ“‚ Article πŸ“… 1993 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 536 KB

Highly specific peptide structures can be designed by inserting dehydro residues into peptide sequences. The peptide N-Boc-L-Phe-dehydro-Phe-L-Val-L-Phe-dehydro-Phe-~-V~-OCH~, synthesized by conventional procedures, crystallizes from methanol-water mixtures at 4Β°C in the tetragonal space group P43 w