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Design of a Genetic Algorithm for the Simulated Evolution of a Library of Asymmetric Transfer Hydrogenation Catalysts

✍ Scribed by Nicolas Vriamont; Bernadette Govaerts; Pierre Grenouillet; Claude de Bellefon; Olivier Riant


Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
703 KB
Volume
15
Category
Article
ISSN
0947-6539

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## Abstract A procedure is described for the automated screening and lead optimization of a supramolecular‐ligand library for the rhodium‐catalyzed asymmetric hydrogenation of five challenging substrates relevant to industry. Each catalyst is (self‐) assembled from two urea‐functionalized ligands a