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Design of a Functional Nitric Oxide Reductase within a Myoglobin Scaffold

✍ Scribed by Valentin Köhler; Thomas R. Ward

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
199 KB
Volume
11
Category
Article
ISSN
1439-4227

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✦ Synopsis

In recent years, significant progress has been made in the computational design of functional artificial enzymes. When combined with directed evolution protocols, their efficiencies are comparable to those obtained with catalytic antibodies. [1] In comparison, the in silico creation of artificial metalloenzymes remains challenging. This could be due to the difficulty in computing both the transition states for metal-catalyzed reactions and the corresponding entatic state for a metalloenzyme. [2] To circumvent these challenges, two complementary approaches have been successfully pursued:

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