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Design of a Cyclopropyl Quinone Methide Reductive Alkylating Agent. 2

✍ Scribed by Khdour, Omar; Ouyang, Anlong; Skibo, Edward B.


Book ID
120324625
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
243 KB
Volume
71
Category
Article
ISSN
0022-3263

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**The cover picture shows** the envisioned pathways for how the DNA methyltransferase, M.HhaI, can use either __S__‐adenosyl‐L‐methionine (SAM; left) or an unnatural aziridinium cofactor (right). The aziridinium ion is proposed to arise in situ from the appropriately functionalized 5β€² N‐mustard prec