Design, machine synthesis, and NMR-solution structure of a β-heptapeptide forming a salt-bridge stabilised 314-helix in methanol and in water

NMR-Solution Structures in Methanol of a

NMR-Solution Structures in Methanol of an α-Heptapeptide, of a β3/β2-Nonapeptide, and of an all-β3-Icosapeptide Carrying the 20 Proteinogenic Side Chains

✍ Dieter Seebach; Raveendra I. Mathad; Thierry Kimmerlin; Yogesh R. Mahajan; Pasca 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 German ⚖ 416 KB

## Abstract The NMR‐solution structure of an __α__‐heptapeptide with a central Aib residue was investigated in order to verify that, in contrast to __β__‐peptides, short __α__‐peptides do not form a helical structures in MeOH. Although the central Aib residue was found to induce a bend in the exper