𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Design criteria for transcriptionally efficient, synthetic genomes

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
42 KB
Volume
102
Category
Article
ISSN
0006-3592

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✦ Synopsis

In addition to ongoing research aimed at enhancing sensor performance (e.g., sensitivity, selectivity, response time), research over the last few decades has focused on the development of novel sensing modalities (e.g., lab-on-a-chip devices and bioassays). The self-referencing technique is a proven sensing modality used in neurobiology, plant physiology, and marine invertebrate physiological applications. Self-referencing converts static concentration sensors into dynamic analyte flux sensors for real-time, noninvasive characterization of active biological transport. McLamore, Porterfield, and Banks introduce the self-referencing sensing modality to the field of biofilm physiology. A reversible enzyme inhibition study was conducted on an environmental biofilm to demonstrate the types of attainable signals lost to signal noise using traditional (non-oscillating) sensing techniques. Use of this sensing modality will advance our understanding of fundamental phenomena concerning chemical toxicity exposure, biodegradation of hazardous compounds, and biocorrosion in biofilm systems.

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