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Design Aspects and Odds Ratio Estimation in Multicenter Case-Control Studies

✍ Scribed by H. Becher; K. Drescher; K.-H. Jöckel

Book ID
102759408
Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
612 KB
Volume
34
Category
Article
ISSN
0323-3847

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✦ Synopsis

In this paper we propose a method to be used in the planning stage of a case-control study. An allocation rule for controls in multicenter case-control studies is proposed which would assure a simple, eflicient and unbiased estimation of the odds ratio in the pooled data. It is shown that the efficiency of the design increases with increasing correlation between study center and risk factor. Sources of bias and their implications for relative risk estimation are discussed. 'The method is demonstrated with data from a case-control study.

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✍ MARKUS NEUHÄUSER; HEIKO BECHER 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 256 KB 👁 1 views

We propose a logistic regression analysis of unmatched or frequency matched case-control studies with conditional maximum likelihood estimation through post hoc stratification. In this model fewer parameters have to be estimated. With a simulation study we show that parameter estimates have smaller