Design and Validation of Bicyclic Iminopyrimidinones As Beta Amyloid Cleaving Enzyme-1 (BACE1) Inhibitors: Conformational Constraint to Favor a Bioactive Conformation

✍ Scribed by Mandal, Mihirbaran; Zhu, Zhaoning; Cumming, Jared N.; Liu, Xiaoxiang; Strickland, Corey; Mazzola, Robert D.; Caldwell, John P.; Leach, Prescott; Grzelak, Michael; Hyde, Lynn; Zhang, Qi; Terracina, Giuseppe; Zhang, Lili; Chen, Xia; Kuvelkar, Reshma; Kennedy, Matthew E.; Favreau, Leonard; Cox, Kathleen; Orth, Peter; Buevich, Alexei; Voigt, Johannes; Wang, Hongwu; Kazakevich, Irina; McKittrick, Brian A.; Greenlee, William; Parker, Eric M.; Stamford, Andrew W.

• Book ID: 115509880
• Publisher: American Chemical Society
• Year: 2012
• Tongue: English
• Weight: 678 KB
• Volume: 55
• Category: Article
• ISSN: 0022-2623
• DOI: 10.1021/jm301039c