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Design and synthesis of tubulin ligands based on epothilones: a preliminary study

✍ Scribed by Sophie Vielle; Eric Raimbaud; Philippe Bertrand; Delphine Quintard; Pierre Renard; Bruno Pfeiffer; Jean-Pierre Gesson

Book ID
104252399
Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
162 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

Starting from the X-ray structure of epothilone B, an original, non macrocyclic, structure has been designed to mimic the key structural features of this potent anticancer agent; the preparation of a key intermediate incorporating four stereogenic centers is described from cyclohexane-1,3-dione.

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