𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Design and Synthesis of Transition State Analogs for Induction of Hydride Transfer Catalytic Antibodies

✍ Scribed by Schröer, Josef; Sanner, Michel; Reymond, Jean-Louis


Book ID
126034219
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
526 KB
Volume
62
Category
Article
ISSN
0022-3263

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Design and synthesis of histone deacetyl
✍ Steven L Colletti; Robert W Myers; Sandra J Darkin-Rattray; Dennis M Schmatz; Mi 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 104 KB

A four step degradation of the C8 ethyl ketone of apicidin provided a route to the C6 aldehyde intermediate and several mechanism-based transition state inhibitors of histone deacetylase. The compounds generated herein delineate the significance of apicidin's side chain, highlighted by the high affi