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Design and Synthesis of the First Spiro Bis(isoxazoline) Derivatives as Asymmetric Ligands

✍ Scribed by Arai, Midori A.; Arai, Takayoshi; Sasai, Hiroaki


Book ID
121247128
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
82 KB
Volume
1
Category
Article
ISSN
1523-7060

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Synthesis of new chiral bis(isoxazoline)
✍ Midori A. Arai; Minori Kuraishi; Takayoshi Arai; Hiroaki Sasai πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 335 KB πŸ‘ 1 views

New chiral bis(isoxazoline) ligands bearing a spiro[5.5]undecane skeleton were designed and synthesized in five steps from diethyl malonate (3). These ligands showed a coordinating ability to Cu(II) as chiral ligands. A complex of (+)-(M\*,S\*,R\*)-[5.5]-SPRIX 2b and Cu(OTf)(2) catalyzed the conjuga