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Design and synthesis of potent tyr(OMe)5-gonadotropin-releasing hormone (GnRH) analogues with modifications at positions 6, 9 and 10

โœ Scribed by Maria Keramida; John M. Matsoukas; George Agelis; Dimitris Panagiotopoulos; John Cladas; Debanada Pati; Graham J. Moore; Hamid R. Habibi

Publisher
Springer Netherlands
Year
1998
Tongue
English
Weight
985 KB
Volume
5
Category
Article
ISSN
1573-3149

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Design and synthesis of a gonadotropin-releasing hormone (GnRH) analogue, [Tyr(OMe)5,d-Glu6,Aze9]GnRH: Receptor binding, gonadotropin release and ovulation studies
โœ Maria Keramida; John M. Matsoukas; Dimitris Panagiotopoulos; Kostas Alexopoulos; ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Springer Netherlands ๐ŸŒ English โš– 344 KB

Gonadotropin-releasing hormone (GnRH) stimulates the release and synthesis of gonadotropin hormones (GtH) and is the key regulator of reproduction. The present study was carried out to design a potent GnRH analogue containing Tyr(OMe) at position 5 and a D-amino acid at position 6. This was based on