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Design and Synthesis of Potent, Non-Peptidic Inhibitors of HPTPβ.

✍ Scribed by Kande K. D. Amarasinghe; et al. et al.

Publisher: John Wiley and Sons
Year: 2006
Weight: 19 KB
Volume: 37
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200651111

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✦ Synopsis

Abstract

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Scheme 1. Synthesis of IFG (1) and IFG derivatives 2-8. a) CH 2 = C(OMe)Me, TsOH•H 2 O, THF, 1.5 h, 0 8C (53 %); b) Tf 2 O, pyridine, CH 2 Cl 2 , 2 h, À78!0 8C; then KCN, 18[crown]-6, DMF, 16 h, RT (80 %); c) RMgX, Et 2 O, 2 h, RT; then NaBH 4 , overnight, RT (65-74 %); d) H 2 , 20 % Pd(OH) 2 /C, Ac