## Abstract For Abstract see ChemInform Abstract in Full Text.
Design and Synthesis of Potent, Non-peptide Inhibitors of HCV NS3 Protease
โ Scribed by Xiaojun Zhang; Aaron C. Schmitt; Wen Jiang; Zelda Wasserman; Carl P. Decicco
- Book ID
- 108477419
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 158 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0960-894X
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๐ SIMILAR VOLUMES
HCV NS3/4A serine protease is essential for the replication of the HCV virus and has been a clinically validated target. A series of HCV NS3/4A protease inhibitors containing a novel acylsulfamoyl benzoxaborole moiety at the P1' region was synthesized and evaluated. The resulting P1-P3 and P2-P4 mac
The Hepatitis C Virus (HCV) is a major health hazard and its infection is a leading cause of chronic liver disease world wide. In our efforts toward the discovery of a back up to our first clinical candidate, Boceprevir (SCH 503034), we approached the depeptidization of the molecule through macrocyc