Design and synthesis of potent and subtype-selective PPARα agonists
✍ Scribed by Ranjit C. Desai; Edward Metzger; Conrad Santini; Peter T. Meinke; James V. Heck; Joel P. Berger; Karen L. MacNaul; Tian-quan Cai; Samuel D. Wright; Arun Agrawal; David E. Moller; Soumya P. Sahoo
- Book ID
- 108073899
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 158 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0960-894X
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract The oxazole ring in a recently reported selective PPARα agonist is replaced by different oxamino groups.
Bioisosteric replacement of the rigid oxazole ring of a previously reported PPARα/γ dual agonist with a flexible lipophilic tail leads to a series of oxime containing benzyl dioxanecarboxylic acid derivatives. Compounds (I) show high selectivity towards PPARα over PPARγ in vitro. Furthermore, the hi
We report here the solid-phase synthesis and vasodepressor potencies of a new lead vasopressin (VP) hypotensive peptide [1(beta-mercapto-beta,beta-pentamethylenepropionic acid)-2-0-ethyl-D-tyrosine, 3-arginine, 4-valine, 7-lysine, 9-ethylenediamine] lysine vasopressin, d(CH(2))(5)[D-Tyr(Et)(2), Arg(