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Design and Synthesis of Pironetin Analogue/Combretastatin A-4 Hybrids and Evaluation of Their Cytotoxic Activity

✍ Scribed by Torijano-Gutiérrez, Sandra; Vilanova, Concepción; Díaz-Oltra, Santiago; Murga, Juan; Falomir, Eva; Carda, Miguel; Marco, J. Alberto

Book ID
121657534
Publisher
John Wiley and Sons
Year
2014
Tongue
English
Weight
684 KB
Volume
2014
Category
Article
ISSN
1434-193X

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A series of cis-locked stilbenic compounds related to combretastatin and combretastatin A4 has been designed and synthesized. The cytotoxic effects of these rigid analogues were evaluated as well as their abilities to inhibit tubulin polymerization.