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Design and synthesis of new bicyclic diketopiperazines as scaffolds for receptor probes of structurally diverse functionality

✍ Scribed by Besada, Pedro; Mamedova, Liaman; Thomas, Craig J.; Costanzi, Stefano; Jacobson, Kenneth A.

Book ID
119963381
Publisher
Royal Society of Chemistry
Year
2005
Tongue
English
Weight
319 KB
Volume
3
Category
Article
ISSN
1477-0520

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Bicyclic sulfonamides were synthesized from 4-alkenyl N-alkenylsulfonyl L-prolines using a ring-closure metathesis reaction. Three types of bicyclic sulfonamides varying in the size of the second ring (5,5; 5,6; 5,7) were synthesized. A sulfonamide counterpart of an indolizidinone 2-carboxylic acid