A series of new 2-[3-(2-alkyloxy-ethyl)-adamantan-1-yl]-ethoxy substituted ether phospholipids was synthesized and their antileishmanial activity was evaluated against Leishmania infantum amastigotes. The majority of the new analogues were significantly less cytotoxic than miltefosine while, antipar
Design and synthesis of multifunctional phospholipids
โ Scribed by Eugenia Drakopoulou; Gerasimos M. Tsivgoulis; Anneke Mukhopadhyay; Alain Brisson *
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 106 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
The synthesis of a bifunctionalized phosholipid capable of binding streptavidin or poly-histidine-tagged proteins is reported for the first time. The head group containing both a biotin and an NTA chelator is synthesized via a new approach using solid phase synthesis.
๐ SIMILAR VOLUMES
The use of conformationally restricted phospholipids 1 and 2 has been employed to understand the conformational preference of phospholipase A2 (PLA2) for substrate phospholipids. Inhibition of porcine pancreatic PLA2 with 1 and 2 indicated a two-to fivefold preference for the distal isomer 2 over th